| Tatiana Maslany | Sarah Manning (and Clones) [SS] | Corinna Riegner |
| Jordan Gavaris | Felix „Fee“ Dawkins [SS] | Tobias Diakow |
| Dylan Bruce | Paul Dierden [SS] | Rainer Fritzsche |
| Kevin Hanchard | Detective Arthur „Art“ Bell [SS] | Fabian Körner |
| Michael Mando | Victor „Vic“ [SS] | Daniel Sellier |
| Maria Doyle Kennedy | Siobhan „Mrs. S.“ Sandler [SS] | Kerstin Fischer |
| Évelyne Brochu | Delphine Cormier [SSR] | Nora Jokhosha |
| Raj [SSR] | Lars Walther |
| Terra Hazelton | Sarah Stubbs [SR] | Ela Paul |
| Michelle Arvizu | La Camarera [SRE] | Claudia Dalchow |
| diverse [SRE] | Susann Sinnemann |
| Dr. Henry Bosch | Simon Böer |
